Best Poison Pokemon Fire Red/Leaf Green (+ movesets)

Poison type Pokemon don’t do a great job of directly killing opponents in Fire Red/Leaf Green, but many of them are dual-type which makes them pretty useful. 

Nidoking is the best Poison type Pokemon in Fire Red/Leaf Green

As for the other Posion types in the game, it’s slim pickings but I think Muk, Gengar, Vileplume, and Tentacruel are probably the best of the rest.

Fire Red/Leaf Green Best Poison Pokemon

The best Posion type Pokemon in Fire Red/Leaf Green is Nidoking (excluding Venusaur which is not available to all players). Not only is Nidoking an absolute tank with a huge move pool, but it’s also one of the earliest third-stage evolution Pokemon you can catch. 

In my opinion, it’s not just the best Poison type, it’s also the best Ground type Pokemon in Fire Red/Leaf Green and the best early- and mid-game Pokemon overall. 


Screenshot of Nidorino evolving into the best poison type Pokemon Nidoking in Pokemon Fire Red Leaf Green

Nidoking is known as the Drill Pokemon and is the final evolution of the male Nidoran (females evolve into Nidoqueen). 

Nidoking is a great all-rounder and has some cool abilities including Poison Point (the user can poison the opponent via contact alone), Rivalry (deals more damage to Pokemon of the same gender), and Sheer Force, which increases the power of moves with secondary effects.

Nidoking base stats (Fire Red/Leaf Green)

Nidoking’s base stat total is 505:

  • HP: 81
  • Attack: 102
  • Defense: 77
  • Sp. Attack: 85
  • Sp. Defense: 75
  • Speed: 85

With beneficial nature plus EVs and IVs, Nidoking’s max stat total at level 100 is 1840.

Best Nidoking Fire Red/Leaf Green moveset

Nidoking can learn pretty much all of the useful TMs in the game so we are spoiled for choice here. 

Same type attack bonus (STAB)-boosted Sludgebomb is your go-to Poison type move (TM36 – it’s in Rocket HQ on Five Island so unfortunately not available early game).

You should almost certainly include the Ground type move Earthquake: It deals a huge amount of damage and benefits from STAB because of Nidoking’s Ground type. 

Megahorn is useful as it is strong against Psychic type Pokemon in Fire Red/Leaf Green (so Nidoking is still a strong option against Sabrina in the Saffron Gym despite its natural weakness to Psychic types).

We can add a powerful Normal move like Thrash to the mix as well. (Important info: You need to wait and evolve Nidorino at level 22 in order for your Nidoking to learn Thrash.)

What is Nidoking strong against?

One of Nidoking’s biggest advantages is the diversity of its move pool. It is able to learn an extensive list of moves via TM and HM and has access to a nice range of moves by level up, too. 

As a dual-type Poison/Ground Pokemon, it is super effective against Grass types in Fire Red & Leaf Green as well as Fire, Rock, and Steel. Other Poison type Pokemon will deal only ¼ damage and Electric type moves have no effect

Nidoking also has basically overpowered HP in the early stages of the game, so I think it’s a must-have in your team. 

What is Nidoking weak against?

While Nidoking does have access to a great range of different moves that make it a difficult opponent for most Pokemon, it does of course have natural type weaknesses.

Water, Ice, Ground, and Psychic type Pokemon are all super effective against Nidoking.

Where to find Nidoking in Fire Red/Leaf Green

Nidoking is easy to obtain early on (the earliest third-stage evolution in the game). 

First, catch a Nidoran. They can be found in the long grass along Route 3 between Pewter City and Mt Moon. You can also trade a female Nidoran for a male Nidoran with the NPC that stands at one end of the Underground Path.

Nidoran evolves into Nidorino at level 16, which can then be evolved immediately into Nidoking using a Moon Stone. This way, you can access the powerful final evolution really early on in the game.

Other strong Poison Pokemon in Fire Red/Leaf Green

If you didn’t pick Bulbasaur and passed on a Nidoran during the early game, the best Poison type options for you are probably Muk, Gengar, Vileplume, or Tentacruel.


Screenshot of encounter with Muk in Pokemon Fire Red Leaf Green

Muk is a gloopy mess of ooze and so is unsurprisingly known as the ‘Sludge Pokemon’.

Muk’s Stench ability helps to repel wild Pokemon which is pretty useful (if Muk is the party leader, wild Pokemon are 50% as likely to appear) and its Sticky Hold ability prevents items from being stolen.

Muk base stats (Fire Red/Leaf Green)

Muk’s base stat total is 500:

  • HP: 105
  • Attack: 105
  • Defense: 75
  • Sp. Attack: 65
  • Sp. Defense: 100
  • Speed: 50

With beneficial nature plus EVs and IVs, Muk’s max stat total at level 100 is 1823.

Best Muk moveset in Fire Red/Leaf Green

On the one hand, Muk has a pretty repsectable HP as well as decent attack stat so the physical type moves will be your friend in a Muk moveset. 

On the other hand, Muk is very slow and its Special Attack is pretty weak. 

Even taking into account the below average Special Attack, I’d go for Sludgebomb for the STAB bonus.

Muk’s wide move pool rescues it somewhat. It can learn both Rain Dance and Thunder which, when used in combination with each other (Thunder’s accuracy is ignored after you use Rain Dance) can be pretty useful.

Finally, Acid Armor (raises the user’s defense by two stages) is worth having in a Muk moveset given its average Defense stat and low speed.  

What is Muk strong against?

Muk is super-effective against Grass types. In addition, both Bug and Fighting type Pokemon in Fire Red/Leaf Green are naturally ineffective against Poison types like Muk.

Any Pokemon of the types mentioned above that also have a low Defense stat (like Buterfree, for example) will be very vulnerable to Muk. 

What is Muk weak against?

Muk is weak against Psychic and Ground types. When you consider that Psychic and Earthquake are two of the best moves in the game, that makes Muk pretty difficult to use in many circumstances.  

Where to catch Muk in Fire Red/Leaf Green

If you’re playing on Leaf Green, you can find Muk in the Pokemon Mansion on Cinnabar Island. Just walk into the mansion and you can encounter Muk in the first corridor. 

If you’re playing on Fire Red, Muk doesn’t appear in the wild in the Pokemon Mansion. It’s  easy to find a Grimer in here, though, which you can then evolve into Muk. 


Screenshot of Haunter evolving into Gengar in Pokmemon Fire Red Leaf Green

Gengar might not be the best Poison Pokemon overall in Fire Red/Leaf Green, but he’s definitely the coolest looking one. 

The ‘Shadow Pokemon’ is the final evolution in the Gastly/Haunter line and there are some fun ways to use it in these games.  

Gengar base stats (Fire Red/Leaf Green)

Gengar’s base stat total is 500:

  • HP: 60
  • Attack: 65
  • Defense: 60
  • Sp. Attack: 130
  • Sp. Defense: 75
  • Speed: 110

With beneficial nature plus EVs and IVs, Gengar’s max stat total at level 100 is 1832.

Best Gengar moveset in Fire Red/Leaf Green

t’s annoying that Ghost type moves in Fire Red/Leaf Green are all physical, because Gengar’s Attack is nothing to write home about. 

Despite this, Gengar can be very irritating to fight against. I like to combine the Special Psychic type moves Hypnosis and Dream Eater – the latter deals serious damage to sleeping enemies. 

Curse is also worth having in your Gengar moveset. As Gengar is a Ghost type, an enemy cursed by this move will have 25% taken from its maximum heath every turn. Gengar loses 50% of its HP by using it but I think that’s a good tradeoff. 

I would probably fill the final space with Thunderbolt to take full advantage of Gengar’s Special Attack.

What is Gengar strong against?

Good luck to anyone who tries to fight Gengar with any Pokemon that has a low Special Defense stat: Gengar’s base Special Attack of 130 is one of the highest in the game.

Normal and Fighting type moves have no effect on Gengar, while Poision and Bug type moves are also extremely ineffective. 

What is Gengar weak against?

Gengar’s natural type weaknesses are Ground, Psychic, Ghost, and Dark. 

Its low HP and Defense stats leave it vulnerable to Pokemon with a decent Attack, as well as the relatively few Pokemon that have a higher Speed than it. 

Something like Dugtrio (Ground type, base Attack 100, base Speed 120), for example, would tear Gengar apart.

Where to catch Gengar in Fire Red/Leaf Green

Gengar does not appear in the wild and can only be obtained in Fire Red/Leaf Green by trading a Haunter (Haunter evolves into Gengar as a result of the trade). 

Haunter is pretty easy to find in the Pokemon Tower in Lavender Town. The Haunters on the seventh (top) floor are higher level and have a higher encounter rate.

If you’re playing on an emulator, that means you’ll have to do some fiddling with the game files to add a Gengar to your team (or you could find a modded game that includes more Pokemon). 


Screenshot of Gloom evolving into Vileplume in Pokemon Fire Red Leaf Green

There’s nothing particularly remarkable about Vileplume, but bear in mind that it’s a Fire Red version exclusive so will be a bit of a hassle to add to your team if you’re playing Leaf Green. 

Vileplume base stats (Fire Red/Leaf Green)

Vileplume’s base stat total is 480:

  • HP: 75
  • Attack: 80
  • Defense: 85
  • Sp. Attack: 100
  • Sp. Defense: 90
  • Speed: 50

With beneficial nature plus EVs and IVs, Vileplume’s max stat total at level 100 is 1807.

Best Vileplume moveset in Fire Red/Leaf Green

Vilepume’s dual Poison/Grass type means we can take advantage of its Chlorophyll ability by using Sunny Day.

Petal Dance is quite a strong STAB move for Vileplume, but it does come with a 50% chance of it Vileplume getting confused after using it. I still think that’s probably worth it (at least until you get access to Sludge Bomb).

A Sunny Day/STAB-boosted SolarBeam is nailed one for one of the spots and I’d go for Stun Spore too.

What is Vileplume strong against?

Vileplume has OK Special Attack stats so its STAB moves like SolarBeam will do plenty of damage against any Pokemon with below-average Special Defense.

Vileplume’s Special Attacks are ultra-effective against other Grass types and they will cause problems for Water type Pokemon in Fire Red/Leaf Green as well as Electric and Fighting.

What is Vileplume weak against?

Vileplume’s defense stats are not a total disaster, but they’re still not at all good. When coupled with an abysmal Speed stat, this makes Vileplume a bit of a sitting duck against any half-decent sweeper.

Where to catch Vileplume in Fire Red/Leaf Green

You’ll need to expose Gloom to a Leaf Stone to get yourself a Vileplume (exposing it to a sun stone will give you Belossom. 

Gloom can be captured fairly easily in Fire Red (it’s a version exclusive) in the lower section of Route 12 once you’ve got Cut and moved Snorlax out of the way using the Pokemon Flute.


Screenshot of encounter with Tentacruel in Pokemon Fire Red Leaf Green

I feel like I’m scraping the barrel here. After all, Tentacruel didn’t make my list of the best Water Pokemon in Fire Red/Leaf Green but, the truth is, Poison types just aren’t that great overall.  

That said, Tentacruel can still cause some trouble for certain opponents.

Tentacruel base stats (Fire Red/Leaf Green)

Tentacruel’s base stat total is 515:

  • HP: 80
  • Attack: 70
  • Defense: 65
  • Sp. Attack: 80
  • Sp. Defense: 120
  • Speed: 100

With beneficial nature plus EVs and IVs, Tentacruel’s max stat total at level 100 is 1861.

Best Tentacruel moveset in Fire Red/Leaf Green

The best moveset I can come up with for Tentacruel in Fire Red/Leaf Green doesn’t use any Posion moves, but it still gets STAB from its Water type.

STAB Surf is a must-have for Tentacruel for obvious reasons. 

Tentacruel can learn the Psychic status move Barrier, which is worth having to pump up that pretty weak defense by a couple of stages. 

I like to combine Hail and Blizzard with Tentacruel. They are Ice type moves so no STAB, but Blizzard has 120 power, and using Hail means that Blizzard’s 70 accuracy is ignored. Nice.

If you don’t want to give up one of your four spots to Hail purely to improve the effectiveness of Blizzard, go for Ice Beam and Giga Drain instead.

What is Tentacruel strong against?

Tentacruel’s best attribute by far is its Special Defense, with a base stat of 120. That gives it great protection against lots of dangerous Pokemon. 

Tentacruel is a duel Poison/Water type and is, therefore, a great option against Fire type Pokemon in Fire Red/Leaf Green.

What is Tentacruel weak against?

If you want to guarantee yourself a bad time, then send Tentacruel out against Ground, Psychic, or Electric types in Fire Red/Leaf Green

Aside from those type weaknesses, any strong Pokemon with a half-decent Attack stat will also be effective against Tentacruel, which suffers from a below-par Defense stat of 65.

Where to catch Tentacruel in Fire Red/Leaf Green

Tentacruel is fair easy to find in Fire Red/Leaf Green. You can encounter them in the wild in various locations on the Sevii Islands.

Tentacool has a much higher encounter rate in these same locations, so another option is to catch one of those and evolve it into a Tentacruel from Level 30. 

Fire Red/Leaf Green best Poison Pokemon – summary

The best Poison type Pokemon in Fire Red/Leaf Green are:

  • Nidoking
  • Muk
  • Gengar
  • Vileplume
  • Tentacruel